De'Broski Herbert is named a Burroughs Wellcome Pathogenesis Awardee 2014-2019

De'Broski R. Herbert Ph.D has been awarded the prestigious Burroughs Wellcome Investigators in the Pathogenesis of Infectious Disease Award. This program is designed to elucidate the intersection of human and pathogen biology. The specific aims of this award are:

AIM 1: To determine whether Trefoil factor peptides down-modulate or skew T lymphocyte effector functions within the pulmonary and gastrointestinal tract

AIM2: Identify the key transcription factor(s) responsible for Trefoil factor-mediated IL-10 release from human macrophages

AIM3: Identify the cell surface receptor(s) responsible for Trefoil factor responsiveness in human macrophages